Echinacoside suppresses cellular senescence of human fibroblastic cells by down-regulation of p53

doi:10.5246/jcps.2011.05.067

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Echinacoside suppresses cellular senescence of human fibroblastic cells by down-regulation of p53

Hui Zhu, Cong Cheng, Chi Zhang, Zhao Wang^*

1. Protein Science Key Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, School of Medicine, Tsinghua University, Beijing 100084, China
2. Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China

Received:2011-03-22 Revised:2011-07-20 Online:2011-09-20 Published:2011-09-20
Contact: Zhao Wang*

Abstract

Abstract:

Echinacoside is one of the phenylethanoids isolated from the stems of Cistanches salsa. Our previous research showed that echinacoside has anti-senescence activity. To investigate the mechanism of echinacoside's anti-senescence activity, the expressions of p53, p21, p16 and Rb at the mRNA and protein levels were determined. Results showed that the expression of p53 was down-regulated significantly in a dose dependent manner after treatment with echinacoside. Further experiments suggested that the down-regulation of p53 may be correlated with the upregulation of SIRT1. In addition, echinacoside may exhibit considerable higher affinity towards SIRT1 than resveratrol, according to our molecular docking simulation. In conclusion, we expect that echinacoside might be a promising candidate for regulating cell senescence.

Key words: Echinacoside, Cellular senescence, p53, SIRT1

CLC Number:

R962.1

Supporting:

Hui Zhu, Cong Cheng, Chi Zhang, Zhao Wang^*. Echinacoside suppresses cellular senescence of human fibroblastic cells by down-regulation of p53 [J]. , DOI: 10.5246/jcps.2011.05.067.

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Echinacoside suppresses cellular senescence of human fibroblastic cells by down-regulation of p53

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