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Improvement for the Synthesis of Centchroman

Xiao Shen Ji, Yi Miao, Yan Liu, Tao Jin, Peng Song   

  1. 1. Department of Clinical Pharmacology; General Hospital of Air Force; Beijing 100036;
    2. Beijing Pharmaceutical Company; Beijing 100006
  • Received:1997-04-04 Revised:1997-09-01 Online:1998-06-15 Published:1998-06-15

Abstract: The synthesis of centchroman has been improved. The hydrogenation under high pressure and configuration transformation in the reported route were omitted. The trans isomer was obtained in highly stereo selective Friedel Crafts alkylation and centchroman was obtained by five steps with the overall yield of 40%.

Key words: Centchroman, Total synthesis

Supporting: