Synthesis and analgesic activities studies on bispiperazinium (BPZ) salts

Abstract

Abstract:

Selecting compound 97-9-G4 as lead compound, a series of bispiperazinium salts 5a-h were designed, synthesized and evaluated for their analgesic activities. The results show that phenylethyl group of 97-9-G4 is a crucial pharmacophore; the introduction of electron-withdrawing group on benzene ring is favorable to the activity.

Key words: Bispiperazinium salt, Bispiperazinium salt, Analgesic activity, Analgesic activity, SAR, SAR, Synthesis, Synthesis

CLC Number:

R916

Supporting:

Qi Sun, Cai-Qin Yue, Jia Ye^*, Chang-Ling Li, Tie-Ming Cheng, Run-Tao Li^**. Synthesis and analgesic activities studies on bispiperazinium (BPZ) salts[J]. .

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