Synthesis of 1-Methylethyl 2-Chloro-5-[[(5,6-dihydro-2-methyl-1,4-oxathiin-3-yl)carbonyl]amino] Benzoate Analogs and Their Antiviral Activity

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Synthesis of 1-Methylethyl 2-Chloro-5-[[(5,6-dihydro-2-methyl-1,4-oxathiin-3-yl)carbonyl]amino] Benzoate Analogs and Their Antiviral Activity

Ji Xiaoshen, Wang Yulun, Zhang Huafeng, Gao Yan, Liu Zhenye, Wang Jiankang

1. Department of Clinical Pharmacology, General Hospital of Air Force, Beijing 100036;
2. Department of Heart Internal Medicine, Tianjin No. 2 Central Hospital, Tianjin 300120

Received:2000-02-25 Revised:2000-08-23 Online:2000-12-15 Published:2000-12-15

Abstract

Abstract: Methylethyl 2-chloro-5-[[(5,6-dihydro-2-methyl-1,4-oxathiin-3-yl)carbonyl] amino] benzoate (UC84) has strong antiviral activity. UC84 was taken as the leading compound and 11 analogs were synthesized. All these compounds were evaluated and some of them showed the obvious anti-HBV and anti-HSV activities. The results indicated that the analogs of 1-methylethyl 2-chloro-5-[[(5,6-dihydro-2-methyl-1,4-oxathiin-3-yl)carbonyl] amino] benzoate (UC84) might be the potential anti-HSV and anit-HBV drugs.

Key words: UC84, UC84, Analogs, Analogs, Synthesis, Synthesis, Antiviral activity, Antiviral activity

Supporting:

Ji Xiaoshen, Wang Yulun, Zhang Huafeng, Gao Yan, Liu Zhenye, Wang Jiankang . Synthesis of 1-Methylethyl 2-Chloro-5-[[(5,6-dihydro-2-methyl-1,4-oxathiin-3-yl)carbonyl]amino] Benzoate Analogs and Their Antiviral Activity[J]. .

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Synthesis of 1-Methylethyl 2-Chloro-5-[[(5,6-dihydro-2-methyl-1,4-oxathiin-3-yl)carbonyl]amino] Benzoate Analogs and Their Antiviral Activity

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