Abstract: Aim To synthesize a new prodrug, resveratrol trinicotinate. Methods In presence of lithium and a catalytic amount of naphthalene, the reaction of p-methoxybenzyl trimethylsilyl ether and 3,5-dimethoxylbenzaldehyde gave resveratrol after a series of translation.Resveratrol trinicotinate was obtained by the reaction of resveratrol and nicotinoyl chloride hydrochloride. Results A mutual prodrug resveratrol trinicotinate was designed and synthesized. Conclusion A novel method for synthesis of resveratrol and resveratrol trinicotinate has been afforded.The E-isomer is selectivily obtained by dehydration of the compound 2 with KHSO4.

Key words: resveratrol, resveratrol, resveratrol trinicotinate, resveratrol trinicotinate, synthesis, synthesis