Structural, morphological, and antibacterial characterization of Eu3+ doped Angelica sinensis polysaccharides

doi:10.5246/jcps.2026.02.009

Abstract

Abstract:

In the present study, a luminescent hybrid material (ASP/Eu) was synthesized by incorporating Eu³⁺ into Angelica sinensis polysaccharides. Comprehensive characterization was conducted to evaluate its thermal stability, aggregate morphology, conformational features, photophysical behavior, and antibacterial activity. Incorporation of Eu enhanced the thermal stability of the polysaccharide matrix while inducing conformational alterations. Congo Red assays indicated that ASP/Eu lacked a triple-helix architecture and instead assembled into more compact sugar-chain aggregates exhibiting fluorescence. Weak luminescence from the Eu-doped polysaccharide was detectable both in the solid state and in aqueous solution, an observation further corroborated by SEM and TEM analyses. The minimum inhibitory concentration (MIC) of ASP/Eu was 800 μg/mL, reducing the survival rate of E. coli to 5.38% ± 0.53% and S. aureus to 4.92% ± 1.49%. These antibacterial assays demonstrated that Eu incorporation significantly improved the bioactivity of the hybrid. Collectively, these findings provided a valuable foundation for advancing the biological exploration and potential applications of ASP/Eu hybrids.

Key words: Luminescent polysaccharide, Morphology, Structure, Antibacterial activity

Supporting:

Jixia Hou, Tengyu Zhang, Jieying Zhao, Ruofei Feng, Chunxia Tan. Structural, morphological, and antibacterial characterization of Eu³⁺ doped Angelica sinensis polysaccharides[J]. Journal of Chinese Pharmaceutical Sciences, 2026, 35(2): 131-143.

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References 32

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Structural, morphological, and antibacterial characterization of Eu³⁺ doped Angelica sinensis polysaccharides

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