Practical and efficient synthesis of myricetin: a scalable approach

doi:10.5246/jcps.2024.12.079

Abstract

Abstract:

Two total synthetic routes for the preparation of myricetin were designed and explored. It was validated that route B presented an efficient approach to synthesizing myricetin, starting from commercially available and inexpensive phloroglucinol. Myricetin was synthesized with an overall yield of 60% across three steps without the need of column chromatography separation. The successful preparation of myricetin on a 25-g scale underscored the potential of this approach.

Key words: Myricetin, Flavonol, Total synthesis, Allan-Robinson reaction

Supporting: /attached/file/20250104/20250104162542_774.pdf

Haijuan Gu, Min Yao, Qi Wang, Lijuan Fan, Wei Zhang, Fang He, Runtao Li, Hao Zhang. Practical and efficient synthesis of myricetin: a scalable approach[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(12): 1101-1109.

Figures/Tables 6

References 26

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