In vitro blood-brain barrier models from different species: an overview on permeability associated with drug delivery

doi:10.5246/jcps.2023.04.021

Abstract

Abstract:

The specific structure of the blood-brain barrier (BBB) leads to the low permeability of central nervous system (CNS) drugs. Many cell-based in vitro BBB models have been developed to aid the study of CNS drug delivery. Mouse, rat, bovine, pig, and human brain endothelial cells are mainly used to build in vitro BBB models. However, interspecies differences in the expressions of transporters, receptors, and tight junction proteins are significant. In this review, several commonly used cell-based in vitro BBB models were introduced. The transendothelial electrical resistance and permeability coefficients of the representative substances, as well as specific endothelial markers, were highlighted. The review provided a clearer overview of these common models and a reference for readers when choosing BBB models.

Key words: Blood-brain barrier, Brain endothelial cell, Drug delivery, In vitro models

Supporting:

Wenjing Ta, Ruochen Hua, Xingyue Li, Jihong Song, Wen Lu. In vitro blood-brain barrier models from different species: an overview on permeability associated with drug delivery[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(4): 237-249.

Figures/Tables 2

References 78

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