Effects and mechanisms of Artemisia argyi essential oil on monocrotaline-induced pulmonary hypertension in rats

doi:10.5246/jcps.2018.03.019

Journal of Chinese Pharmaceutical Sciences ›› 2018, Vol. 27 ›› Issue (3): 183-192.DOI: 10.5246/jcps.2018.03.019

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Effects and mechanisms of Artemisia argyi essential oil on monocrotaline-induced pulmonary hypertension in rats

Yin Ying^1,2, Yunfeng Sun¹, Hongchun Li¹, Bo Yang¹, Hui Wang¹, Qingmei Wu¹, Ping Huang^3*

1. Department of Pharmacy, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China
2. Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang 310007, China
3. Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China

Received:2017-11-16 Revised:2018-01-17 Online:2018-03-31 Published:2018-02-10
Contact: Tel.: +86-13858024909, E-mail: hangzhou_hp@163.com
Supported by:
The Natural Science Foundation of Zhejiang Province of China (Grant No. LQ14H280003), the TCM Project of Zhejiang Province (Grant No. 2011ZA006), and the Chinese Integrative Medicine Foundation of Zhejiang Province (Grant No. 2013LYSX020), Zhejiang Provincial Program for the Cultivation of High-level Innovative Heath Talents (Ping Huang), Zhejiang 151 Elites Project, the second level (Ping Huang).

Abstract

Abstract:

In the present study, we aimed to investigate the effects of Artemisia argyi essential oil (AO) on pulmonary hypertension (PH)inducedbymonocrotaline(MCT)andtoexploretheunderlying mechanism.A total of 80 Sprague-Dawley ratswererandomlydividedintofourgroups as follows:controlgroup, modelgroup,bosentan(0.1g/kg)groupandAO(0.1g/kg)group.After30dofexperiment, hemodynamicparameters,lungandrightventricle hypertrophy indexweredetermined. HEand Immunohistochemistrystainingoflungs were performedto detectthe injuriesandprotein expressions. Theresultsshowedthatlevels of mPAP,mRVP,maxRVP,wW,LI,RV and RVHI as well asthe expressionsofNF-κBp65andα-SMA were increased,smallpulmonaryarterythickened, the cavity of the arteriole narrowed, and there was marked infiltration of inflammatory cells in lungs of rats receiving MCT compared with the normal group. After the administration of AO, the levels of mPAP and mRVP were significantly decreased,and the wW, LI, LV+S and pulmonary arterial remodeling were markedly improved. The expression levels of NF-κB p65 and α-SMAwerereduced by AOcomparedwiththe modelgroup.Ourresultssuggestedthat AOreduced the progressionof PH induced byMCTthroughinhibiting the expressions of NF-κB p65 and α-SMA.

Key words: Artemisia argyi essential oil, Pulmonary hypertension, NF-κB, α-SMA

CLC Number:

R962

Supporting:

Yin Ying, Yunfeng Sun, Hongchun Li, Bo Yang, Hui Wang, Qingmei Wu, Ping Huang. Effects and mechanisms of Artemisia argyi essential oil on monocrotaline-induced pulmonary hypertension in rats[J]. Journal of Chinese Pharmaceutical Sciences, 2018, 27(3): 183-192.

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Effects and mechanisms of Artemisia argyi essential oil on monocrotaline-induced pulmonary hypertension in rats

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