Cardioprotective effects of combination of notoginseng total saponins and safflower total flavonoids against myocardial infarction in rats

doi:10.5246/jcps.2018.02.013

Abstract

Abstract:

In this study, the cardioprotective mechanism of the combination of notoginseng total saponins and safflower total flavonoids (CNS) was investigated due to its excellently efficacy against myocardial infarction (MI) in rats. After the left anterior descending coronary artery (LADCA) ligation, rats were orally administered with CNS for 7 consecutive days. CNS prevented MI-induced pathophysiological changes and significantly decreased plasma levels of myocardial enzymes, including creatine kinase MB isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST). Further investigation revealed that CNS attenuated the production of inflammatory factors in plasma, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β). Moreover, CNS treatment decreased the expression of caspase-3 at the mRNA level in infarct tissue. Our findings demonstrated that the anti-inflammatory and anti-apoptotic properties of CNS might confer its cardioprotection against MI in rats.

Key words: Myocardial infarctions, Inflammation, Apoptosis, Notoginseng Radix et Rhizoma, Carthami Flos

CLC Number:

R284

Supporting:

Yuqing Meng, Lichao Wang, Yan Li, Jinyang Song, Zhiyong Du, Chun Li, Yong Jiang, Pengfei Tu, Xiaoyu Guo. Cardioprotective effects of combination of notoginseng total saponins and safflower total flavonoids against myocardial infarction in rats[J]. Journal of Chinese Pharmaceutical Sciences, 2018, 27(2): 116-122.

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