Quality evaluation of heat stress treated Radix saposhnikoviae using pharmacokinetic and pharmacologic methods

doi:10.5246/jcps.2018.02.012

Abstract

Abstract:

The quality of Radix saposhnikoviae (RS) had deteriorated due to the adoption of cultivated plants rather than wild plants. High temperature treatment increases the content of several chromones, however using one or more individual constituents would be difficult to determine the medical quality of RS. In this paper, we used pharmacokinetic and pharmacologic approaches to evaluate the quality of RS. The active constituents were analysed using pharmacokinetic parameters of the chromone derivatives, and the antipyretic, analgesic, and anti-inflammatory effects were evaluated by pyretic animal model, hot plate test, and ear edema model, respectively. Only cimifugin was found in plasma after RS and heat-stress-RS were administered to rats, with a 50.6% increase in AUC_0–_{24 h} of cimifugin in the latter. Likewise, more potent anti-pyretic, analgesic, and anti-inflammatory activities were also found in the latter. Exposure of S. divaricata fresh roots to high temperatures enhanced the antipyretic, analgesic, and anti-inflammatory effects of RS by promoting the absorption of cimifugin.

Key words: Radix Saposhnikoviae, Chromone, Pharmacokinetics, Anti-pyretic, Analgesic, Anti-inflammatory

CLC Number:

R969.1

Supporting:

Hua Jiang, Jingming Yang, Ling Cao, Guizhi Jia, Hongliang Dai, Xiangcai Meng. Quality evaluation of heat stress treated Radix saposhnikoviae using pharmacokinetic and pharmacologic methods[J]. Journal of Chinese Pharmaceutical Sciences, 2018, 27(2): 109-115.

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