Synthesis of the arsenic-containing amino-acids, and their potential applications in peptide chemistry

doi:10.5246/jcps.2017.05.040

Abstract

Abstract:

Trivalent organoarsenic compounds have attracted a great deal of interest because of their potential antineoplastic activities. In this work, we synthesized a series of arsenic-containing amino acid analogues by introducing the structure of 1-arsino-2,6,7-trithiobicyclo[2.2.2]octane to the side chain of modified amino acid derivatives. The protected amino acid (6a) as a typical objective compound was applied in peptide synthesis via the classic procedures for the formation of peptide bond or removal of protecting groups. Our results showed that the application of compound 6a (or 5a) in the peptide chemistry was satisfactory.

Key words: Organoarsenic compound, Amino acid, Peptide chemistry

CLC Number:

R916

Supporting:

Yajuan Shi, Qinghua Guan, Yanfen Wu, Chao Wang. Synthesis of the arsenic-containing amino-acids, and their potential applications in peptide chemistry[J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(5): 372-378.

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