Vanadyl complexes work with cinnamaldehyde in promoting cell viability under the β­amyloid burden in SH­SY5Y neural cells

doi:10.5246/jcps.2016.10.084

Abstract

Abstract:

The Alzheimer’s disease (AD) is one of the common cognitive disorders in the elderly. AD shares some similar pathological characters with diabetes mellitus (DM), suggesting potential application of anti-diabetic agents, such as vanadyl complexes, in therapeutic treatment of AD. In the present work, we studied the effects of vanadyl acetylacetonate (VO(acac)₂) and cinnamaldehyde (CA) on an AD model based on SH-SY5Y neural cells. The experimental results showed that VO(acac)₂ at sub-micromolar concentrations could improve the viability of neural cells with or without increased βamyloid (Aβ) burden; and the combination of VO(acac)₂ and CA showed an additive cell protection effects. Further investigation revealed that for SH-SY5Y neural cells, VO(acac)₂ could activate PPARγ-AMPK signal transduction and inhibit GSK 3β, one of the major kinases for Tau hyperphosphorylation. Meanwhile, CA could correct the abnormal mitochondrial morphology due to Aβ-induced excessive mitochondrial fission, thus restoring/enhancing the mitochondrial function. In addition, both VO(acac)₂ and CA decreased intracellular reactive oxygen species (ROS) level and inhibited formation of toxic Aβ oligomers. Overall, VO(acac)₂ might work with CA in improving the neural cell viability under the Aβ burden, suggesting application of vanadium metallodrugs in AD treatment.

Key words: Alzheimer’s disease, βAmyloid, SH-SY5Y cells, Vanadium, Cinnamaldehyde

CLC Number:

R915

Supporting:

Xue Li, Lidan Bai, Yaqiong Dong, Qing Chang, Rui Wu, Jing Zhang, Xiaoda Yang. Vanadyl complexes work with cinnamaldehyde in promoting cell viability under the βamyloid burden in SHSY5Y neural cells[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(10): 754-763.

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