Flavonoids: emerging trends and potential health benefits

doi:10.5246/jcps.2014.12.103

Abstract

Abstract:

Flavonoids are widely used in industry for the prevention of various diseases. In daily life we are directly in touch with flavonoids due to their presence in different beverages, fruits and vegetables. Flavonoids are mainly used as a coloring agent in plants, antioxidant and nutritional food for human. Flavonoids have explicit role in UV filtration, symbiotic nitrogen fixation and floral pigmentation. Flavonoids have potential for different biological activities like chelation of metals, decreasing platelets aggregation and cell signaling etc.

Key words: Flavones, Antioxidant, Flavonols, Nutraceutical

CLC Number:

R284

Supporting:

Raj K. Keservani, Anil K. Sharma. Flavonoids: emerging trends and potential health benefits[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(12): 815-822.

References

[1] Mobh, S. J. Biochem. 1938, 29, 487-501.

[2] Vauzour, D.; Vafeiadou, K.; Rodriguez, M.A.; Rendeiro, C.; Spencer, J.P. Genes Nutr. 2008, 3, 115-126.

[3] Harborne, J.B.; Williams, C.A. 1992, 55, 481-504.

[4] Manach, C.; Scalbert, A.; Morand, C.; Remesy, C.; Jimenez, L. Am J. Clin. Nutr. 2004, 79, 727-747.

[5] Peer, W.A.; Murphy, A.S. Trends Plant Sci. 2007, 12, 556-563.

[6] Mol, J.; Grotewold, E.; Koes, R. Trends Plant Sci. 1998, 3, 212-217.

[7] Doll, R.; Peto, R. J. Natl. Cancer. Inst. 1981, 66, 1192-1308.

[8] Willett, W.C. Nutritional Epidemiology, 2nd. Oxford University Press, New York. 1998.

[9] Kuhnau, J. World Rev. Nutr. Diet. 1976, 24, 117.

[10] Middleton, J.E.; Kandaswami, C. The Flavonoids: Advances in research (Harborne, J.B.), Chapman & Hall, London. 1994, 619-652.

[11] Robards, K.; Antolovich, M. Analyst. 1997, 122, R11.

[12] Escarpa, A.; Gonzalez, M.C. Crit. Rev. Anal. Chem. 2001, 31, 57.

[13] Bhagwat, S.; Haytowitz, D.B.; Holden, J.M. Release 3. Beltsville, MD: USDA. 2011,

[14] Corcoran, M.P.; McKay, D.L.; Blumberg, J.B. J. Nutr. Gerontol. Geriatr. 2012, 31, 176-189.

[15] Von, K.S.; Rossbach, G. Chem. Ber. 1896, 29, 1488-1494.

[16] Augustyn, J.A.N.; Bezuidenhoudt, B.C.B.; Ferreira, D. Tetrahedron. 1990a, 46, 2651-2660.

[17] Claisen, L.; Claparede, A. Chem. Ber. 1881, 14, 2460-2468.

[18] Katsuki, T.; Sharpless, K.B. J. Am. Chem. Soc. 1980, 102, 5974-5976.

[19] Johnson, R.A.; Sharpless, K.B. Catalytic asymmetric epoxidation of allylic alcohols, in catalytic asymmetric synthesis (Ojima, L.), VCH Publishers, New York, 1993, 103-158.

[20] Jacobson, E.N. Asymmetric catalytic epoxidation of unfuctionalized olefins, in Catalytic asymmetric synthesis (Ojima, L.), VCH Publishers, New York, 1993, 159-202.

[21] Geissman, T.A.; Fukushima, D.K. J. Am. Chem. Soc. 1948, 70, 1686-1689.

[22] Dean, F.; Podimuang, V. J. Chem. Soc. 1965,3978-3987.

[23] Saxena, S.; Makrandi, J.K.; Grover, S.K. Synthesis. 1985, 110-111.

[24] Patonay, T.; Toth, G.; Adam, W. Tetrahedron. 1993, 34, 5055-5058.

[25] Donnelly, J.A.; Doran, H.J. Tetrahedron. 1975, 31, 1565-1569.

[26] Donnelly, J.A.; Fox, M.J.; Sharma, T.C. Tetrahedron. 1979, 35, 1987-1991.

[27] Donnelly, J.A.; Emerson, G.M. Tetrahedron. 1990, 46, 7227-7236.

[28] Donnelly, J.A.; Higginbotham, C.L. Tetrahedron. 1990, 46, 7219-7226.

[29] Koukol, J.; Conn, E.E. J. Biol. Chem. 1979, 136, 2692-2698.

[30] Dixon, R.A.; Paiva, N.L. Plant Cell. 1995, 7, 1085-1097.

[31] Shirley, B.W. Trend. Plant Sci. 1996, 1, 377-382.

[32] Blaut, M.; Schoefer, L.; Braune, A. Int. J. Vitam. Nutr. Res. 2003, 73, 79-87.

[33] Markham, K.R.; Mabry, T.J. Ultraviolet-visible and proton magnetic resonance spectroscopy of flavonoids, in the flavonoids ( Harborne, J.B.; Mabry, T.J.; Mabry, H.), Chapman and Hall, London, 1975, 45-77.

[34] Cuyckens, F.; Claeys, M. J. Mass Spectrom. 2004, 39, 1-15.

[35] Stobiecki, M.; Wojtaszek, P. J. Chromatogr. 1990, 508, 391-398.

[36] Reddy, G.M.; Coe, E.H.J. Science. 1962, 138, 149-150.

[37] Marrs, K.A.; Alfenito, M.R.; Lloyd, A.M.; Walbot, V. Nature. 1995, 375, 397-400.

[38] Alfenito, M.R.; Souer, E.; Goodman, C.D.; Buell, R.; Mol, J.; Koes, R.; Walbot, V. Plant Cell. 1998, 10, 1135-1149.

[39] Dixon, D.P.; Lapthorn, A.; Edwards, R. Genome Biol. 2002, 3, 1-10.

[40] Peer, W.A.; Brown, D.E.; Tague, B.W.; Muday, G.K.; Taiz, L.; Murphy, A.S. Plant Physiol. 2001, 126, 536-548.

[41] Buer, C.S.; Muday, G.K. Plant Cell. 2004, 16, 1191-1205.

[42] Saslowsky, D.E.; Warek, U.; Winkel, B.S.J. J. Biol. Chem. 2005, 280, 23735-23740.

[43] Notoya, M.; Tsukamoto, Y.; Nishimura, H.; Woo, J.T.; Nagai, K.; Lee, I.S.; Hagiwara, H. Eur. J. Pharm. 2004, 485, 89-96.

[44] Ye, R.Q.; Goodarzi, A.A.; Kurz, E.U.; Saito, S.; Higashimoto. Y.; Lavin, M.F.; Appella, E.; Anderson, C.W.; Lees-Miller, S.P. DNA Repair. 2004, 3, 235-244.

[45] Mizushina, Y.; Ishidoh, T.; Kamisuki, S.; Nakazawa, S.; Takemura, M.; Sugawara, F.; Yoshida, H.S.; Sakaguchi, K. Biochem. Biophys. Res. Commun. 2003, 301, 480-487.

[46] Constantinou, A.; Mehta, R.; Runyan, C.; Rao, K.; Vaughan, A.; Moon, R. J. Nat. Prod. 1995, 58, 217-225.

[47] Boege, F.; Straub, T.; Kehr, A.; Boesenberg, C.; Christiansen, K.; Andersen, A.; Jakob, F.; Kohrle, J. J. Biol. Chem. 1996, 271, 2262-2270.

[48] Ito, T.; Warnken, S.P.; May, W.S. Biochem. Biophys. Res. Commun. 1999, 265, 589-594.

[49] Marko, D.; Puppel, N.; Tjaden, Z.; Jakobs, S.; Pahlke, G. Mol. Nutr. Food Res. 2004, 48, 318-325.

[50] Trompier, D.; Baubichon-Cortay, H.; Chang, X.B.; Maitrejean, M.; Barron, D.; Riordon, J.R.; Di, P.A. Cell Mol. Life. Sci. 2003, 60, 2164-2177.

[51] Almela, M.J.; Irurzun, A.; Carrasaco, L. Antiviral. Chem. Chemother. 1994, 5, 99-104.

[52] Ale-Agha, N.; Stahl, W.; Siss, H. Biochem. Pharmacol. 2002, 63, 2145-2149.

[53] Lim, M.; McKenzie, K.; Floyd, A.D.; Kwon, E.; Zeitlin, P.L. Am. J. Resp. Cell. Mol. Biol. 2004, 31, 351-357.

[54] Montero, M.; Lobaton, C.D.; Hernandez-Sanmiguel, E.; Santodomingo, J.; Vay, L.; Moreno, A.; Alverez, J. J. Biochem. 2004, 384, 19-24.

[55] Lee, E.H.; Meissner, G.; Kim, D.H. J. Biophys. 2002, 82, 1266-1277.

[56] Pan, M.H.; Chen, W.J.; Lin-Shiau, S.Y.; Ho, C.T.; Lin, J.K. Carcinogenesis. 2002, 23, 1677-1684.

[57] Beniston, R.G.; Campo, M. Virus. Res. 2005, 109, 203-209.

[58] Galeotti, F.; Barile, E.; Curir, P.; Dolci, M.; Lanzotti, V. Phytochem. Lett. 2008, 1, 44-48.

[59] Keservani, R.K.; Kesharwani, R.K.; Vyas, N.; Jain, S.; Raghuvanshi, R.; Sharma, A.K. Der Pharmacia. Lett. 2010, 2, 106-116.

[60] Keservani, R.K.; Sharma, A.K.; Kesharwani, R.K.; Vyas, N.; Chadoker, A. Int. J. Curr. Pharm. Rev. Res. 2010, 1, 59-75.

[61] Ross, J.A.; Kasum, C.M. Annu. Rev. Nutr. 2002, 22, 19-34.

[62] Kelm, M.A.; Hammerstone. J.F.; Schmitz, H.H. Clin. Dev. Immunol. 2005, 12, 35-41.

[63] Schreier, P. Dev. Ophthalmol. 2005, 38, 1-58.

[64] Nordeen, S.K.; Bona, B.J.; Jones, D.N. Horm. Cancer. 2013, 4, 293-300.

[65] Heijnen, C.G.; Haenen, G.R.; Van Acker, F.A.; Van der Vijgh, W.J.; Bast, A. Toxicol. In Vitro. 2001, 15, 3-6.

[66] Chun, O.K.; Kim, D.O.; Lee, C.Y. J. Agric. Food Chem. 2003, 51, 8067-8072.

[67] Williams, R.J.; Spencer, J.P.; Rice-Evans, C. Free. Radic. Biol. Med. 2004, 36, 838-849.

[68] Frei, B.; Higdon, J.V. J. Nutr. 2003, 133, 3275-3284.

[69] Lotito, S.B.; Frei, B. Free. Radic. Biol. Med. 2006, 41, 1727-1746.

[70] Sankhalkar, S.Am. J. Pharm. Tech. Res. 2014, 4, 254-270.

[71] Janitzio, X.K.P.S.; Cuauhtemoc, R.M.; Mario, A.G. Plant Foods Hum. Nutr. 2014, 1, 1-7.

[72] Mira, L.; Fernandez, M.T.; Santos, M.; Rocha, R.; Florencio, M.H.; Jennings, K.R. Free Radic. Res. 2002, 36, 1199-1208.

[73] Cheng, I.F.; Breen, K. Biometals. 2000, 13, 77-83.

[74] Spencer, J.P.; Rice-Evans, C.; Williams, R.J. J. Biol. Chem. 2003, 278, 34783-34793.

[75] Spencer J.P.; Schroeter, H.; Crossthwaithe, A.J.; Kuhnle, G.; Williams, R.J.; Rice-Evans, C. Free Radic. Biol. Med. 2001, 31, 1139-1146.

[76] Kong, A.N.; Owuor, E.; Yu, R. Drug Metab. Rev. 2001, 33, 255-271.

[77] Walle, U.K.; Walle, T. Drug Metab. Dispos. 2002, 30, 564-569.

[78] Chen, J.J.; Ye, Z.Q.; Koo, M.W. BJU Int. 2004, 93, 1082-1086.

[79] Wang, W.; VanAlstyne, P.C.; Irons, K.A.; Chen, S.; Stewart, J.W.; Birt, D.F. Nutr. Cancer. 2004, 48, 106-114.

[80] Stewart, Z.A.; Westfall, M.D.; Pietenpol, J.A. Trends Pharmacol. Sci. 2003, 24, 139-145.

[81] Bagli, E.; Stefaniotou, M.; Morbidelli, L. Cancer Res. 2004, 64, 7936-7946.

[82] Kim, M.H. J. Cell Biochem. 2003, 89, 529-538.

[83] Deng, X.; Zhao, X.; Lan, Z. J. Med. Food. 2014, 17, 787-794.

[84] Naso, L.; Valcarcel, M.; Villace, P. New J. Chem. 2014, 38, 2414-2421.

[85] O’Leary, K.A.; De, P.T.S.; Needs, P.W.; Bao, Y.P.; O’Brien, N.M.; Williamson, G. Mutat. Res. 2004, 551, 245-254.

[86] Sakata, K.; Hirose, Y.; Qiao, Z.; Tanaka, T.; Mori, H. Cancer Lett. 2003, 199, 139-145.

[87] Cho, S.Y.; Park, S.J.; Kwon, M.J. Mol. Cell. Biochem. 2003, 243, 153-160.

[88] Steele, V.E.; Hawk, E.T.; Viner, J.L.; Lubet, R.A. Mutat. Res. 2003, 523-524, 137-144.

[89] Philips, N.; Bynum, D.; Hwang, H. Anti-Inflamm. Anti-All. Ag. 2014, 9, 142-149.

[90] Anter, E.; Thomas, S.R.; Schulz, E.; Shapira, O.M.; Vita, J.A.; Keaney, J.F.J. J. Biol. Chem. 2004, 279, 46637-46643.

[91] Duffy, S.J.; Vita, J.A. Curr. Opin. Lipidol. 2003, 14, 21-27.

[92] Deana, R.; Turetta, L.; Donella-Deana, A. Thromb. Haemost. 2003, 89, 866-874.

[93] Bucki, R.; Pastore, J.J.; Giraud, F.; Sulpice, J.C.; Janmey, P.A. J. Thromb. Haemost. 2003, 1, 1820-1828.

[94] Hubbard, G.P.; Wolffram, S.; Lovegrove, J.A.; Gibbins, J.M. Proc. Nutr. Soc. 2003, 62, 469-478.

[95] Vita, J.A. J. Nutr. 2003, 133, 3293-3297.

[96] Yang, C.S.; Yang, G.Y.; Landau, J.M.; Kim, S.; Liao, J. Exp. Lung. Res. 1998, 24, 629-639.

[97] Ramassamy, C. Eur. J. Pharmacol. 2006, 545, 51-64.

[98] Jennings, A.; Welch, A.A.; Spector, T. J. Nutr. 2014, 144, 202-208.

[99] Lorenzen, N. J. Biol. Chem. 2014, 289, 21299-21310.

[100] Okuyama, S.; Morita, M.; Miyoshi, K.; Nishigawa, Y. Neurochem. Int. 2014, 70, 30-38.

[101] Bar-Meir, S.; Halpern, Z.; Gutman, M. Gut. 1985, 26, 975-979.

[102] Conn, H.O. Hepatol. 1983, 3, 121-123.