Use of Solid SMEDDS in Delivery of Carvedilol

Abstract

Abstract: Aim A new solid SMEDDS (self-microemulsifying drug delivery system) capsule has been developed to increase the solubility and dissolution rate. Methods The solubilities of carvedilol in various bases were investigated. Ternary phase diagrams were used to evaluate the self-emulsification and self-microemulsfication domains. The particle size distribution and ζ-potential were determined. The mean diameter of the three formulae decreased with an increase of Lutrol F68. Results The in vitro dissolution rate of carvedilol from solid SMEDDS capsule was significantly increased, compared with that from commercially available tablets. Conclusion The solid self-microemulsifying capsule showed the potential of improving the bioavailability of carvedilol.

Key words: self-microemulsification, self-microemulsification, carvedilol, carvedilol, particle size distribution, particle size distribution, ζ-potential, ζ-potential, dissolution, dissolution

CLC Number:

R943.4

R944.5

Supporting:

WEI Lan-lan, SUN Pei-nan, TIAN Lei, TANG Xin, YAO Ting-ting, PAN Wei-san^*. Use of Solid SMEDDS in Delivery of Carvedilol[J]. .

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