Chemical constituents from the stems of Homalium ceylanicum

doi:10.5246/jcps.2014.03.021

Journal of Chinese Pharmaceutical Sciences

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Chemical constituents from the stems of Homalium ceylanicum

Yuan Cao, Lei Liu, Zhiqin Guo, Qiang Guo, Yong Jiang, Xingyun Chai*, Pengfei Tu*

1. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China

Received:2013-12-02 Revised:2013-12-23 Online:2014-03-13 Published:2013-12-30
Contact: *Corresponding author. Tel.: 86-10-82802859; 86-10-64286350; E-mail: pengfeitu@vip.163.com; xingyunchai@yeah.net
About author:*Corresponding author. Tel.: 86-10-82802859; 86-10-64286350; E-mail: pengfeitu@vip.163.com; xingyunchai@yeah.net
Supported by:
Program for Changjiang Scholar and Innovative Team in University (Grant No. 985-2-063-112).

Abstract

Abstract:

By means of solvent extraction and repeated chromatography on silica gel, Sephadex LH-20, HPLC, and preparative TLC, the ethanol extract of the stems of Homalium ceylanicum (Flacourtiaceae/Salicaceae sensu lato) was chemically investigated, which led to the isolation of 13 constituents, including five lignans (1–5) and three isocoumarins (6–8). Based on the spectroscopic analysis and comparison of its ¹H NMR and ¹³C NMR data with those in literatures, their structures were identified as (–)-5'-methoxyisolariciresinol 3α-O-β-D-glucopyranoside (1), (+)-lyoniresinol 3α-O-β-D-glucopyranoside (2), (+)-isolarisiresinol 3α-O-β-D-glucopyranoside (3), (–)-isolarisiresinol 3α-O-β-D-glucopyranoside (4), icariside E5 (5), 3-phenylisocoumarin (6), homalicine (7), (–)-dihydrohomalicine (8), friedelin (9), 4-hydroxybenzoic acid (10), catechol (11), methyl-α-arabinofuranoside (12), and uridine (13). All isolates except compounds 6–8 were described from this genus for the first time. Compound 6 was isolated from this species for the first time.

Key words: Homalium ceylanicum, Flacourtiaceae, Salicaceae sensu lato, Homalium, Chemical constituent

CLC Number:

R932

Supporting:

Yuan Cao, Lei Liu, Zhiqin Guo, Qiang Guo, Yong Jiang, Xingyun Chai, Pengfei Tu. Chemical constituents from the stems of Homalium ceylanicum[J]. Journal of Chinese Pharmaceutical Sciences, DOI: 10.5246/jcps.2014.03.021.

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Chemical constituents from the stems of Homalium ceylanicum

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