Preparation and physicochemical characterization of solid dispersion of quercetin and polyvinylpyrrolidone

Abstract

Abstract: Aim The objective of this study was to prepare and characterize quercetin-polyvinylpyrrolidone (Qurc-PVP) solid dispersion with the intention of improving its dissolution properties. Methods Qurc-PVP solid dispersion was prepared by solvent method. The release rate of quercetin was determined from dissolution studies and the physicochemical properties of solid dispersion were investigated by differential scanning calorimetry (DSC), infrared spectroscopy (IR), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM). Results The results showed that the dissolution rate of quercetin was significantly improved by solid dispersion compared to that of the pure drug and physical mixture. Solubility studies revealed a markedly increase in the solubility of quercetin. The results of DSC and PXRD showed that the quercetin in solid dispersion was amorphous form. From SEM analysis, there was no quercetin crystal observed in the solid dispersions. Conclusion The solubility and dissolution of quercetin were improved by solid dispersion technique.

Key words: Quercetin, Quercetin, Polyvinylpyrrolidone PVP, Polyvinylpyrrolidone PVP, Solid dispersion, Solid dispersion, Dissolution rate, Dissolution rate

CLC Number:

Supporting:

Jing Zhu, Zhao-GangYang, Xiao-Mei Chen, Jia-Bei Sun, Gulisitan Awuti, Xuan Zhang^*, Qiang Zhang. Preparation and physicochemical characterization of solid dispersion of quercetin and polyvinylpyrrolidone[J]. .

References

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