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A new synthesis route of cabazitaxel

Guoning Zhang, Weishuo Fang*   

  1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • Received:2012-05-09 Revised:2012-07-25 Online:2012-09-15 Published:2012-09-15
  • Contact: Weishuo Fang*

Abstract:

A new route for the synthesis of cabazitaxel (Javanta®) starting with 10-deacetylbaccatin III was developed. In this new procedure, a mild condition for the methylation of 7-OH was applied, thus the epimerization of 7β-OH under basic conditions was reduced. The total yield of this 6-step synthesis is 20%.

Key words: Cabazitaxel, 7-OH Methylation

CLC Number: 

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