Abstract:

Direct chiral separation of azelnidipine enantiomers with Pirkle-type Sumichiral OA-2500 column was studied by normal phase and reserve phase conditions. By normal phase, azelnidipine enantiomers were well separated with Rs as 4.0 using hexane-ethanol (90:10, v/v) as mobile phase, and Rs as 2.7 in shorter time (no more than 13 min) using hexane-ethanol (60:40, v/v) as the recommended mobile phase. They were only partially separated by reverse phase using methanol or methanol containing 0.05 mol/L ammonium acetate. Using same chiral column, the chiral separation of other dihydropyridine calcium antagonist analogues almodipine and nimodipine were also studied and showed partial chiral separation in normal phase.

Key words: Chiral separation, Azelnidipine, Almodipine, Nimodipine

CLC Number: 

• R917.01

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