http://jcps.bjmu.edu.cn

• Original articles • Previous Articles     Next Articles

Efficient synthesis of thiohydantoin derivatives from amino acid esters and isothiocyanates in alkaline Al2O3

Gang Li, Yu-Peng Liu, Meng Lei, Xin Wang*, Tie-Ming Cheng, Run-Tao Li*   

  1. State Key Laboratory of Natural and Biomimetic Drugs; Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China
  • Received:2011-11-11 Revised:2011-01-15 Online:2012-03-15 Published:2012-03-15
  • Contact: Xin Wang*, Run-Tao Li*

Abstract: Various amino acid esters were reacted with different isothiocyanates in alkaline Al2O3 at room temperature for 1 h affording thiohydantoins in moderate to excellent yields.

Key words: Thiohydantoin, Amino acid ester, Isothiocyanate, Alkaline Al2O3, Synthesis

CLC Number: 

Supporting: