Preparation and characterization of oleanolic acid-loaded solid lipidnanoparticles for oral administration

doi:10.5246/jcps.2011.03.032

Abstract

Abstract:

Oleanolic acid-loaded solid lipid nanoparticles (OA-SLNs) were prepared by using an improved emulsion-solvent evaporation method. The size, zeta potential, encapsulation efficiency, and loading efficiency of OA-SLNs were (104.5±11.7) nm, (-25.5±1.8) mV, (94.2±3.9)%, and (4.71±0.15)%, respectively. The morphology was illustrated by TEM as sphere stuffed particles. The XRD and DSC spectra confirmed that the OA molecules were dispersed uniformly into SLN matrixes. The results of in vitro release test suggested that OA was released slowly at a rate of 4.88% per hour from SLN preparation, which was consistent with the Zero-order Released Model. In addition, OA-SLNs were stable in artificial gastric juice and artificial intestinal juice. Together, our results provided new data for the potential application of OA-SLNs in oral administration.

Key words: Oleanolic acid, Solid lipid nanoparticles, Preparation, Characterization

CLC Number:

R943.4

Supporting:

Hui Sun, Xian-Hua Zhang, Shuo Wang, Ying-Feng Tu, Rong-Sheng Zhao^*, Ying Xie^* . Preparation and characterization of oleanolic acid-loaded solid lipid
nanoparticles for oral administration [J]. , DOI: 10.5246/jcps.2011.03.032.

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Preparation and characterization of oleanolic acid-loaded solid lipid
nanoparticles for oral administration

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