Application of 3D printing technology in the treatment of bacterial inflammation: oral formulations, internal implants, and external dressings

doi:10.5246/jcps.2026.01.002

Abstract

Abstract:

As bacterial infections have emerged as the second leading cause of death worldwide, the urgent demand for novel and effective antibacterial therapies continues to escalate. In this context, three-dimensional (3D) printing technology offers transformative potential for the design and fabrication of oral formulations, internal implants, and external dressings in the management of bacterial inflammation. Conventional oral antibacterial agents often suffer from limitations in drug release kinetics and gastrointestinal stability. Leveraging 3D printing enables precise control over drug release profiles, thereby enhancing both bioavailability and therapeutic efficacy. Moreover, the development of internal implants requires high levels of individual specificity and structural precision. Through patient-specific customization and the incorporation of appropriate antibacterial materials, 3D printing allows the fabrication of implants tailored to individual clinical needs, ultimately increasing surgical success rates and minimizing postoperative infection risks. Additionally, 3D-printed external dressings exhibit excellent antibacterial activity, accelerate wound healing, and facilitate patient recovery. This review summarizes the fabrication methods, key advantages, and therapeutic outcomes of 3D printing in oral delivery systems, implantable devices, and wound dressings. It further highlights recent advances and emerging trends, offering insights and strategic guidance for the rational design and application of antibacterial therapeutics.

Key words: 3D printing, Antimicrobial drug delivery, Oral formulations, Internal implants, External dressings

Supporting:

Zanyan Gao, Shiyu Gao, Maomei Xie, Chen Chen, Yongyuan Li, Guangcheng Jia, Rui Liu, Haixia Wang. Application of 3D printing technology in the treatment of bacterial inflammation: oral formulations, internal implants, and external dressings[J]. Journal of Chinese Pharmaceutical Sciences, 2026, 35(1): 16-37.

Figures/Tables 1

References 88

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