Preparation and antibacterial activities of metal complexes of norfloxacin

doi:10.5246/jcps.2021.10.072

Journal of Chinese Pharmaceutical Sciences ›› 2021, Vol. 30 ›› Issue (10): 838-844.DOI: 10.5246/jcps.2021.10.072

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Preparation and antibacterial activities of metal complexes of norfloxacin

Ahsan Zamir Siddiqi¹^,², Muneeba Akhtar³, Agha Zeeshan Mirza⁴^,^*()

1 Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan
2 Highnoon Laboratories Limited, Lahore, Pakistan
3 Department of Pharmaceutics, Faculty of Pharmacy, University of Central Punjab, Lahore-54782, Pakistan
4 Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia

Received:2021-04-12 Revised:2021-06-17 Accepted:2021-07-11 Online:2021-10-24 Published:2021-10-24
Contact: Agha Zeeshan Mirza

Abstract

Abstract:

The metal complexes of norfloxacin were prepared, and their structures were characterized using spectroscopic techniques like IR, ¹H NMR, UV, atomic absorption, and CHN analysis. The solubility, melting point, and conductance measurements were also performed. These studies suggested that norfloxacin formed complexes with the metals utilizing carbonyl oxygen atom of the ring and carboxylic group oxygen atom. The antibacterial activities of these metal complexes against 14 different Gram-positive and Gram-negative microorganisms were studied by the disk susceptibility method. It was observed that the complexes of norfloxacin with magnesium, calcium, cobalt, nickel, and copper showed improved activity compared with the stated drug.

Key words: Norfloxacin, Metal complexes, Characterization, Antibacterial activities

Supporting:

Ahsan Zamir Siddiqi, Muneeba Akhtar, Agha Zeeshan Mirza. Preparation and antibacterial activities of metal complexes of norfloxacin[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(10): 838-844.

Figures/Tables 7

Table 1. Physical characteristics of norfloxacin metal complex.

Table 2. Proton NMR assignments of norfloxacin and its metal complexes.

Table 3. Elemental analysis of norfloxacin and its metal complexes.

Table 4. Zone of inhibition (mm) of norfloxacin and its metal complexes.

Table 5. Zone of inhibition (mm) of norfloxacin and its metal complexes.

References 18

[1]	Vincent, T.A. The Quinolones, Academic Press. 1998, 2^nd edition, 89, 31.
[2]	Siddiqui, F.A.; Arayne, M.S.; Sultana, N.; Mirza, A.Z.; Zuberi, M.H.; Qureshi, F. Med. Chem. Res. 2010, 19, 1259.
[3]	Scott, L.D. Antibacterial Chemotherapeutic Agents, Blackie Academic and Professional, 1997, 298.
[4]	Neu, H.C.; Labthavikul, P. Antimicrob. Agents Chemother. 1982, 22, 23.
[5]	Chen, L.; Hu, Y. Chin. J. Magn. Resonance. 1987, 4, 155.
[6]	Gao, F.; Yang, P.; Xie, J.; Wang, H. J. Inorg. Biochem. 1995, 60, 61.
[7]	Campbell, N.R.C.; Kara, M.; Hasinoff, B.B. Br. J. Clin. Pharmacol. 1992, 33, 115.
[8]	Shiba, K.; Sakamoto, M.; Nakazawa, Y.; Sakai, O. Drugs. 1995, 49, 360.
[9]	Siddiqui, F.A.; Arayne, M.S.; Sultana, N.; Qureshi, F.; Mirza, A.Z.; Shehnaz, H. Chem. Anal. (Warsaw). 2009, 54, 1465.
[10]	Anamika, D.; Firasat, H.; Dhanraj, T.M. Bioinorganic Chem. Applications. Article. 2014, ID 457478, 1.
[11]	Sultana, N.; Araye, M.S.; Siddiqi, A.Z.; Mirza, A.Z. Synthesis and antibacterial studies of ciprofloxacin-metal complexes. J. Chin. Pharm. Sci. 2019, 28, 422–429.
[12]	Arayne, M.S.; Sultana, N.; Mirza, A.Z. J. Mol. Struct. 2009, 927, 54–59.
[13]	Bauer, A.W.; Kirby, W.M.M.; Sherris, J.C.; Turck, M. Am. J. Clin. Pathol. 1966, 45, 493.
[14]	Freddo, R.J.; Dalla, C.T. J. Pharm. Sci. 2002, 91, 2433.
[15]	Jamil, A.M. Acta Chim. Solv. 2002, 49, 457.
[16]	Marija, Z.; Iztok, T.; Peter, B.; Andrew, J.P.W.; David, J.W. Croat. Chem. Acta. 2001, 74, 61.
[17]	Marija, Z.; Iztok, A.; Peter ,B.; Alojz, K. Croat. Chem. Acta. 2002, 75, 1.
[18]	Victor, L.M.D. Antibiotics in Laboratory Medicine. Williams and Wilkins, 1991, 3^rd edition, 17.

Preparation and antibacterial activities of metal complexes of norfloxacin

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