Chemical constituents of the aerial parts of Glycyrrhiza uralensis and their inhibitory activities against PTP1B and α-glucosidase

doi:10.5246/jcps.2020.05.028

Journal of Chinese Pharmaceutical Sciences ›› 2020, Vol. 29 ›› Issue (5): 305-313.DOI: 10.5246/jcps.2020.05.028

• Original articles • Next Articles

Chemical constituents of the aerial parts of Glycyrrhiza uralensis and their inhibitory activities against PTP1B and α-glucosidase

Jingran Fan^1,2, Zeyuan Dong², Yi Kuang², Yanxia Zhou², Xue Qiao², Min Ye^2*

1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2020-03-14 Revised:2020-04-15 Online:2020-05-31 Published:2020-05-10
Contact: Tel.: +86-10-82801516, Fax: +86-10-82802024, E-mail: yemin@bjmu.edu.cn
Supported by:
National Natural Science Foundation of China (Grant No. 81891010/81891011), National Mega-project for Innovative Drugs (Grant No. 2018ZX09711001-008-003), and Science & Technology Department of Xinjiang Uygur Autonomous Region (Grant No. 2018AB012).

Abstract

Abstract:

In the present study, a total of 11 compounds were isolated from the aerial parts of Glycyrrhiza uralensis, including two new compounds, glycyuralin Q (1) and glycyuralin R (2), and nine known compounds, including licoriphenone (3), orobol (4), trifoliol (5), 7,2′,4′-trihydroxy-5-methoxy-3-arylcoumarin (6), 11-hydroxy-9(Z),12(Z)-octadecadienoic acid (7), 11-hydroxy-9(E),12(E)-octadecadienoic acid (8), licoricone (9), glycyrin (10), and 2′-hydroxyformononetin (11). Structures of the new compounds were identified by 1D, 2D NMR and HR-MS data analyses. Compounds 1, 2 and 10 showed potent inhibitory activities against PTP1B, with IC₅₀ values of 1.43, 4.71 and 3.79 μM, respectively. Compounds 2, 4 and 10 inhibited α-glucosidase with IC₅₀ values of 13.61, 11.13 and 17.48 μM, respectively.

Key words: The aerial parts, PTP1B, α-Glucosidase, Glycyrrhiza uralensis

CLC Number:

R284

Supporting:

Jingran Fan, Zeyuan Dong, Yi Kuang, Yanxia Zhou, Xue Qiao, Min Ye. Chemical constituents of the aerial parts of Glycyrrhiza uralensis and their inhibitory activities against PTP1B and α-glucosidase[J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(5): 305-313.

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Chemical constituents of the aerial parts of Glycyrrhiza uralensis and their inhibitory activities against PTP1B and α-glucosidase

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