The inhibitory activities of Urtica fissa to BPH

doi:10.5246/jcps.2020.04.022

Journal of Chinese Pharmaceutical Sciences ›› 2020, Vol. 29 ›› Issue (4): 236-243.DOI: 10.5246/jcps.2020.04.022

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The inhibitory activities of Urtica fissa to BPH

Jin Huang, Lingxin Yang, Ning Yang, Bowen Yuan, Hao Zhang, Mengyue Wang^*

School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China

Received:2020-02-26 Revised:2020-03-12 Online:2020-04-30 Published:2020-03-14
Contact: Tel.: +86-21-34205222; Fax: +86-21-34204804, E-mail: mywang@sjtu.edu.cn
Supported by:
National Natural Science Fund of China (Grant No. 81374067), Shanghai Municipal Health Commission (Grant No. 2018ZY002), and College Students’ Innovation Project (Grant No. IPP20216).

Abstract

Abstract:

In the present study, the BPH inhibitory activities of Urtica fissa were systematically investigated. Firstly, inhibitory activities of 5α reductase of the alcoholic extracts from different parts (root, stem, leaf, flower and fruit) were evaluated. The results indicated that the root possessed the most significant action. Subsequently, U. fissa root (UFR) was subjected to further pharmacological evaluation using the benign prostate hyperplasia (BPH) model rats induced by testosterone propionate. The results revealed that UFR could significantly decrease the prostate index, alter the hyperplasia tissue morphology, suppress the prostatic growth factors of VEGF, EGF, bFGF and KGF, decrease the inflammation factor levels of TNF-α, IL-1βand IL-6, improve the activities of GSH-Px, CAT and SOD and decrease the MDA level in the prostate of the model rats. Moreover, UFR also significantly suppressed the hormone levels of testosterone and dihydrotestosterone. These results indicated that the possible BPH inhibitory mechanisms of UFR were growth factor suppression, hormone level modulation, anti-inflammation, and anti-oxidative stress.

Key words: Urtica fissa root, BPH, 5α-Reductase, Growth factor suppression, Anti-inflammation activity, Anti-oxidative stress, Hormone level modulation

CLC Number:

R284

Supporting:

Jin Huang, Lingxin Yang, Ning Yang, Bowen Yuan, Hao Zhang, Mengyue Wang. The inhibitory activities of Urtica fissa to BPH[J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(4): 236-243.

References

[1] Chen, J.R.; Lin, Q.; Friis, I.; Wilmot-Dear, C.M.; Monro, A.K. Flora of China (Vol. 5). Beijing: Science Press, and St. Louis: Missouri Botanical Garden Press. 2003, 78-84.

[2] Chinese Materia Medica Editorial Board. Chinese Materia Medica (2). Shanghai: Shanghai Science and Technology Press. 1999, 584.

[3] Wang, M.Y.; Feng, X.R.; Zhang, C.Q.; Cheng, J.; Liu, E.J.; Sun, L.A.; Li, X.B. The chemical constituents in the decoction of Urtica fissa rhizomes. J. Chin. Pharm. Sci. 2016, 25, 764-770.

[4] European Directorate for the Quality Control of Medicines. European Pharmacopoeia 9.0. 2016, 1450.

[5] Zhang, L.L.; Lu, X.; Wang, H.G.; Feng, B.M. Progress in the action of Urtica genus on prostatic diseases. Central. South Pharm. 2015, 13, 616-619.

[6] Su, R.N.; Wei, R.R.; Luo, W.Z.; Zhu, J.X.; Wang, L.; Zhong, G.Y. Study on effect of extract from Tibetan medicine Urtica hyperborean on anti-prostatic hyperplasia. Chin. J. Chin. Mater. Med. 2019, 44, 1953-1959.

[7] Wang, Y.L.; Lu, X.; Cao, H.Y.; Feng, B.M. Study of the molecular docking of Urtica compounds against benign prostatic hyperplasia and pharmacokinetic properties. Chin. J. Clin. Pharmacol. 2019, 35, 2104-2018.

[8] Mitamura. K.; Ogasawara, C.; Shiozawa, A.; Terayama, E.; Shimada, K. Determination method for steroid 5 alpha-reductase activity using liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry. Anal. Sci. 2005, 21, 1241-1244

[9] Murata, K.; Noguchi, K.; Kondo, M.; Onishi, M.; Watanabe, N.; Okamura, K. Inhibitory activities of Puerariae Flos against testosterone 5α-reductase and its hair growth promotion activities. J. Nat. Med. 2012, 66, 158-165.

[10] Wu, X.; Gu, Y.; Li, L. The anti-hyperplasia, anti-oxidative and anti-inflammatory properties of Qing Ye Dan and swertiamarin in testosterone-induced benign prostatic hyperplasia in rats. Toxicol. Lett. 2017, 265, 9-16.

[11] Ribal, M.J. The link between benign prostatic hyperplasia and inflammation. Eur. Urol. Suppl. 2013, 12, 103-109.

The inhibitory activities of Urtica fissa to BPH

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