Discovery of tryptamine derivatives from Bacillus sp. PKU-TA00001

doi:10.5246/jcps.2019.08.050

Abstract

Abstract:

Tryptamine-derived natural products have been discovered from different sources including animals, plants and bacteria,and they show various biological activities. However, they are not discovered widely compared with the large amounts of tryptaminederivatives generated by chemical synthesis. We here report the discovery of five tryptamine-derived natural products (1–5) and one known polyketide 6 from Bacillus sp. PKU-TA00001. Compounds 1 and 2are new compounds featuring methyl-hexanamide moieties, compound 4is first discovered as a natural product, and 3 and 4’s NMR data are first provided. All compounds showed MIC (minimum inhibitory concentration) values higher than 50 µM against several Gram-positive and negative strains, and showed no cytotoxicity at the concentration of 100 µM against the human cancer cell lines A549, HCT-8 and MCF-7. The discovery of 1–4expands the structural diversity of tryptamine-derived natural products, and sets the stage for revealing their biosynthetic mechanisms and biological activities in the future.

Key words: Bacillus, Strain prioritization, Tryptamine-derived natural products

CLC Number:

R284

Supporting:

Tongtong Geng, Guiyang Wang, Xueyang Ma, Zhongyi Zhang, Tan Liu, Yuanjie Ge, Jing Jin, Xiaoxu Sun, Yingtao Zhang, Donghui Yang, Ming Ma. Discovery of tryptamine derivatives from Bacillus sp. PKU-TA00001[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(8): 527-536.

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