The correlation and consistency of light transmission aggregometry and thrombelastography in identifying high clopidogrel on-treatment platelet reactivity in patients with acute coronary syndrome

doi:10.5246/jcps.2016.11.094

Journal of Chinese Pharmaceutical Sciences ›› 2016, Vol. 25 ›› Issue (11): 838-845.DOI: 10.5246/jcps.2016.11.094

• Drug administration and clinical pharmacy column • Previous Articles Next Articles

The correlation and consistency of light transmission aggregometry and thrombelastography in identifying high clopidogrel on-treatment platelet reactivity in patients with acute coronary syndrome

Xiaoyan Nie¹, Yang Xu², Yu Fu¹, Junlei Li¹, Guangkai Liang¹, Yong Zhang³, Yun Lu⁴, Jian Liu^3*, Luwen Shi^1*

1. School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2. School of Public Health, Peking University Health Science Center, Beijing 100191, China
3. Department of Cardiology, Peking university people’s hospital, Beijing 100044, China
4. Department of Pharmacy, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA

Received:2016-09-15 Revised:2016-10-29 Online:2016-11-26 Published:2016-11-06
Contact: Tel.: +86-010-82805019, +86-010-88326216, E-mail: niexy@bjmu.edu.cn, drjianliu@163.com, shilu@bjmu.edu.cn
Supported by:
Beijing Higher Education Young Elite Teacher Project (Grant No. YETP0064) from Beijing Municipal Education Commission.

Abstract

Abstract:

Various platelet function tests are currently used to identify responsiveness to antiplatelet therapy. 176 ACS patients were enrolled and Linear regression and Kappa consistency analysis showed there was a significant but moderate correlation between platelet inhibition rate and a significant but fair agreement between high clopidogrel on-treatment platelet reactivity tested by light transmission aggregometry and thrombelastography.

Key words: Light transmission aggregometry, Thrombelastography, Clopidogrel, High platelet reactivity, Consistency

CLC Number:

R954

Supporting:

Xiaoyan Nie, Yang Xu, Yu Fu, Junlei Li, Guangkai Liang, Yong Zhang, Yun Lu, Jian Liu, Luwen Shi. The correlation and consistency of light transmission aggregometry and thrombelastography in identifying high clopidogrel on-treatment platelet reactivity in patients with acute coronary syndrome[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(11): 838-845.

References

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The correlation and consistency of light transmission aggregometry and thrombelastography in identifying high clopidogrel on-treatment platelet reactivity in patients with acute coronary syndrome

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