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Development of new solid phase extraction techniques in the last ten years

Huixia Fan, Zhipeng Deng, Hao Zhong, Qingqiang Yao*   

  1. 1. Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China
    2. School of Medicine and Life Sciences, University of Jinan and Shandong Academy of Medical Sciences, Jinan 250022, China
    3. Key Laboratory of Rare and Uncommon Diseases of Shandong Province, Jinan 250062, China
  • Received:2012-10-29 Revised:2013-01-05 Online:2013-07-10 Published:2013-07-10
  • Contact: Qingqiang Yao*

Abstract: Solid phase extraction (SPE) is a widely used sample pretreatment method for separation, purification and enrichment, which has been established due to its significant advantages of time-saving, low consumption of solvent, high enrichment factor, high accuracy, etc. In recent years, a variety of new SPE methods such as molecularly imprinted solid phase extraction (MISPE), magnetic solid phase extraction (MSPE), solid phase micro-extraction (SPME), etc., which are superior to the conventional SPE, have been developed and been widely applied to food, drugs, and environmental monitoring. In this paper, the basic principles and methods of SPE and its new applications in different areas are reviewed.

Key words: Solid phase extraction, Molecularly imprinted solid phase extraction, Magnetic solid phase extraction, Solid phase micro-extraction

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