Two new furostanol glycosides from Asparagus cochinchinensis (Lour.) Merr.

doi:10.5246/jcps.2013.02.029

• Original articles • Previous Articles

Two new furostanol glycosides from Asparagus cochinchinensis (Lour.) Merr.

Rui Jian, Jun Li, Kewu Zeng, Ning Li, Yong Jiang, Pengfei Tu^*

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

Received:2012-10-21 Revised:2013-01-08 Online:2013-03-18 Published:2013-03-18
Contact: Pengfei Tu*

Abstract

Abstract:

Two new furostanol glycosides, aspacochinosides L (1) and M (2), were isolated from the roots of Asparagus cochinchinensis (Lour.) Merr. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1 and 2 were investigated for their anti-neuroinflammatory activity in LPS-induced BV-2 cells. Compound 2 showed moderate inhibitory effect on NO production in LPS-induced BV-2 microglial cells with IC50 value of 32.26 μM.

Key words: Asparagus cochinchinensis, Steroidal saponin, Furostanol glycoside, Aspacochinoside

CLC Number:

R284

Supporting:

Rui Jian, Jun Li, Kewu Zeng, Ning Li, Yong Jiang, Pengfei Tu^*. Two new furostanol glycosides from Asparagus cochinchinensis (Lour.) Merr.[J]. , DOI: 10.5246/jcps.2013.02.029.

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Two new furostanol glycosides from Asparagus cochinchinensis (Lour.) Merr.

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