Abstract:

Two protected single amino acid chelates, N^α-Fmoc-N^ε, N^ε-di((2,2-dimethyl-1, 3-dithian-5-yl)methyl)-L-lysine (7) and N^α-Fmoc-N^ε-(2,2-dimethyl-1,3-dithian-5-yl)methyl, N^ε-Boc-L-lysine (9), were synthesized by modifying the side chain of lysine with 1,3-dithiane through direct reductive N-alkylation protocol. These amino acids have potential uses in peptide chemistry.

Key words: Amino acid chelate, 1,3-Dithiane, Reductive N-alkylation

CLC Number: 

• R916

Supporting: