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A practical and efficient procedure for the α-bromination of arylethanones

Rui-Juan Xing, Li Pan, Xi Wen, Jian Wang, Mao-Sheng Cheng*   

  1. Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
  • Received:2009-12-23 Revised:2010-07-30 Online:2010-09-20 Published:2010-09-20
  • Contact: Mao-Sheng Cheng*

Abstract:

A series of α-bromoarylethanones were prepared in high yields by a practical and efficient method. The arylethanones were reacted with bromine to give a mixture of α- and α, α-dibromides, which were debrominated with diethylphosphite in the presence of triethylamine to give the desired α-monobromo products.

Key words: α-Bromoarylethanones, Bromine, Diethylphosphite, α-Bromination

CLC Number: 

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