Comparison of different polysaccharide-based chiral stationary phases for enantioselective resolution of Naftopidil and its derivatives by HPLC

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Comparison of different polysaccharide-based chiral stationary phases for enantioselective resolution of Naftopidil and its derivatives by HPLC

Xia-Wen Liu, Mu Yuan^*, Hong Ji

The Pharmaceutical Research Center of Guangzhou Medical College, Guangzhou 510182, China

Received:2010-03-22 Revised:2010-06-10 Online:2010-07-15 Published:2010-07-15
Contact: Mu Yuan*

Abstract

Abstract:

Effective enantioseparation of Naftopidil and its derivatives by HPLC was accomplished using several different polysaccharide-based chiral stationary phases (CSPs). In normal-phase mode, the compounds were eluted on four coated- and two immobilized-columns with the mixture of n-hexane, isopropanol and diethylamine (DEA). Polysaccharide tris(3,5-dimethylphenyl carbamate) was shown to be the best enantiomer selector. In addition, the immobilized column packed with Chiralpak IA or IB was applied under polar-organic and reversed-phase conditions, both of which exhibited excellent enantioselectivity for Naftopidil and its derivatives. Furthermore, the underlying possible chiral recognition mechanisms were discussed.

Key words: Polysaccharide-based chiral stationary phases, Enantioselective separation, Naftopidil and its derivatives

CLC Number:

R917.01

Supporting:

Xia-Wen Liu, Mu Yuan^*, Hong Ji . Comparison of different polysaccharide-based chiral stationary phases for enantioselective resolution of Naftopidil and its derivatives by HPLC [J]. .

Comparison of different polysaccharide-based chiral stationary phases for enantioselective resolution of Naftopidil and its derivatives by HPLC

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