Synthesis of podophyllotoxin derivative GL331 and identification of it binding site on topoisomerase IIα with molecular modeling

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Synthesis of podophyllotoxin derivative GL331 and identification of it binding site on topoisomerase IIα with molecular modeling

Chi-Wen Hu, Ying-Xiang Liu^*

College of Chinese Traditional Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China

Received:2009-11-29 Revised:2009-12-15 Online:2010-01-15 Published:2010-01-15
Contact: Ying-Xiang Liu*

Abstract

Abstract: A facile one-pot procedure has been developed for the synthesis of GL331 in 26% overall yield. In addition, molecular modeling study was carried out to predict the binding site of GL331 with human topoisomerase IIα. The result showed that GL331 exhibited high affinity for the ATPase domain of human topoisomerase IIα and suggested that GL331 probably acts as a competitor of ATP for binding with the human topoisomerase IIα.

Key words: Synthesis, GL331, Topoisomerase IIα, Molecular docking

CLC Number:

R916

Supporting:

Chi-Wen Hu, Ying-Xiang Liu^*. Synthesis of podophyllotoxin derivative GL331 and identification of it binding site on topoisomerase IIα with molecular modeling [J]. .

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Synthesis of podophyllotoxin derivative GL331 and identification of it binding site on topoisomerase IIα with molecular modeling

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