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Synthesis of a novel class of cyclophosphamide bis-spiropiperazinium salts

Mo Liu, Ze-Mei Ge*, Tie-Ming Cheng, Run-Tao Li*   

  1. State Key Laboratory of Natural and Biomimetic Drugs; Department of Chemical Biology, School of Pharmaceutical Science, Peking University, Beijing 100191, China
  • Received:2009-05-19 Revised:2009-10-15 Online:2009-11-30 Published:2009-11-30
  • Contact: Ze-Mei Ge*, Run-Tao Li*

Abstract: Based on the principle of association, a novel class of cyclophosphamide bis-spiropiperazinium compounds was designed and synthesized. A new method of synthesis, separation and purification for this kind of compounds was also developed.

Key words: Cyclophosphamide bis-spiropiperazinium salt, Cyclophosphamide bis-spiropiperazinium salt, Principle of association, Principle of association, Synthesis, Synthesis, Anti-cancer, Anti-cancer

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