Vasorelaxant effect of 3,4-dihydro-2-(4-morpholinylmethy)-1(2H)-naphthalenone on the vascular smooth muscle of rabbits

Abstract

Abstract:

The purpose of this study was to examine the relaxation effect of CY on the vascular smooth muscle (VSM) from rabbits. Experiments were carried out on isolated thoracic aorta of rabbits. CY (3×10^–3mM – 3 mM) could relax the VSM preparations pre-contracted by adrenaline (AD), noradrenaline (NE), high-K⁺solution or BaCl2 with respective EC50 values of (0.31±0.11) mM, 0.19±0.03 mM, 0.20±0.04 mM and 0.25±0.04 mM. Moreover, CY (10^–2 mM, 0.1 mM and 1 mM) inhibited norepinephrine (NE), CaCl2 and KCl-induced vasoconstriction in a concentration dependent manner. The phasic contraction produced by NE was concentration dependently attenuated with CY (10^–2 mM, 0.1 mM and 1 mM) in calcium-free medium, similar to that caused by verapamil. The present findings suggest that CY relaxed thoracic aortic rings by blocking voltage-dependent Ca²⁺ channels. The inhibition of intracellular Ca²⁺release may be one of the main vasorelaxant mechanisms of CY.

Key words: 3,4-Dihydro-2-(4-morpholinylmethy)-1(2H)-naphthalenone, 3,4-Dihydro-2-(4-morpholinylmethy)-1(2H)-naphthalenone, Vascular smooth muscle, Vascular smooth muscle, Ca2+ channels, Ca2+ channels, Rabbit, Rabbit

CLC Number:

R972

Supporting:

Xue Li, Yuan-Yuan Wei, Shou-Ting Fu^*, Lan Zhu, Bing Wang. Vasorelaxant effect of 3,4-dihydro-2-(4-morpholinylmethy)-1(2H)-naphthalenone on the vascular smooth muscle of rabbits [J]. .

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Vasorelaxant effect of 3,4-dihydro-2-(4-morpholinylmethy)-1(2H)-naphthalenone on the vascular smooth muscle of rabbits

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