Optimization of the biphasic release of indomethacin from HPMC/pectin/calcium chloride matrix tablet by response surface methodology

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Optimization of the biphasic release of indomethacin from HPMC/pectin/calcium chloride matrix tablet by response surface methodology

Bao-Jian Wu, Xiu-Li Wei, Yi Lu, Wei Wu^*

Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China

Received:2008-07-21 Revised:2008-11-10 Online:2008-12-15 Published:2008-12-15
Contact: Wei Wu*

Abstract

Abstract: We studied the effect of two independent variables, the pectin/calcium chloride weight ratio and the overall matrix weight in HPMC/pectin/calcium matrix tablet, on the release of indomethacin. A two-factor 5-level central composite experimental design was employed. Responses of the Peppas correlation parameters n and K and the 10% release time (T0.1) were optimized by response surface methodology. Significant effect of the independent variables on the biphasic release parameters, n and K, was observed. N, K and T0.1 were well fitted with the second-order quadratic equations rather than linear equations. Moreover, the mathematic fitting and the response surfaces showed significant cross-interaction between the pectin/calcium chloride ratio and the overall matrix weight. The optimal formulation with larger n, longer T0.1 and smaller K consisted of medium pectin/calcium chloride ratio around 1.0 and medium matrix weight around 200 mg. Validation studies on the optimal formulations showed good predictability of the n, K and T0.1 values with biases within the range of -7.33% and 6.26%. Our results support that central composite design can be used to optimize drug release from HPMC/pectin/calcium matrix tablet with high predictability.

Key words: Drug release, Drug release, Optimization, Optimization, Response surface, Response surface, Indomethacin, Indomethacin, Pectin, Pectin, Matrix, Matrix, ,

Supporting:

Bao-Jian Wu, Xiu-Li Wei, Yi Lu, Wei Wu^*
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Optimization of the biphasic release of indomethacin from HPMC/pectin/calcium chloride matrix tablet by response surface methodology

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