Augmentative effect of tetrandrine on pentobarbital hypnosis mediated by 5-HT1A and 5-HT2A/2C receptors in mice

Abstract

Abstract: It has been reported that augmentative effect of tetrandrine on pentobarbital hypnosis in mice may be related to serotonergic system. The present study was undertaken to investigate the interaction of tetrandrine and different 5-HT receptors on pentobarbital-induced sleep by using the loss-of-righting reflex method. The results showed that augmentative effect of tetrandrine on pentobarbital hypnosis in mice were potentiated by the p-MPPI (5-HT1A receptor antagonist) (1 mg/kg, i.p.) and ketanserin (5-HT2A/2C receptor antagonist) (1.5 mg/kg, i.p.), respectively. Pretreatment with either 8-OH-DPAT (5-HT1A receptor agonist) (0.1 mg/kg, s.c.) or DOI (5-HT2A/2C receptor agonist) (0.2 mg/kg, i.p.) significantly decreased pentobarbital-induced sleep time, and tetrandrine (60 mg/kg, i.g.) significantly reversed this effect. These results suggest that both the 5-HT1A and 5-HT2A/2C subfamily may be involved in the potentiating mechanism of tetrandrine’s effects on pentobarbital hypnosis.

Key words: Tetrandrine, Tetrandrine, Pentobarbital hypnosis, Pentobarbital hypnosis, 5-HT1A receptor, 5-HT1A receptor, 5-HT2A/2C receptor, 5-HT2A/2C receptor

CLC Number:

R964

Supporting:

Nan Du, Li-En Wang, Xiao-Rong Shi, Xiang-Yu Cui, Su-Ying Cui, Fan Zhang, Yong-He Zhang^*. Augmentative effect of tetrandrine on pentobarbital hypnosis mediated by 5-HT1A and 5-HT2A/2C receptors in mice
[J]. .

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