Abstract:

Aim To synthesize dutasteride. Methods The target compound was synthesized from pregnenolol via eight steps, including esterification, oxidation, hydrolysis, then oxidative ring-opening, cyclization, reduction, oxidization and finally acylation. Results The structure of the target molecule was identified by 1H NMR, 13C NMR and element analysis. The overall yield was 31.5%. Conclusion The effects of different reaction conditions on the yield of product in each step have been investigated and the optimal reaction conditions have been established.

Key words: Steroid hormones, Steroid hormones, Dutasteride, Dutasteride, Pregnenolol, Pregnenolol, Inhibition of 5α-reductase, Inhibition of 5α-reductase