In Vitro Skin Permeation of Osthol from Hydro-Alcoholic Gel Formulations

Abstract

Abstract: Aim To evaluate the in vitro percutaneous absorption behavior of osthol from a series of hydro-alcoholic gel formulations containing three penetration enhancers through excised human skin (stratum cormeum and epidermis,SCE). Methods Excised human skin was mounted in Franz-type diffusion cells. The samples withdrawn from the receptor cell were analyzed for osthol content by high-performance liquid chromatography (HPLC). Results The enhancers azone, menthol and chenopodium increased the osthol percutaneous steady-state fluxes 3.12, 2.00 and 1.25 times those of the enhancer-free formulations (controls), separately. Conclusions The main enhancement mechanism of the skin penetration enhancers azone, menthol and chenopodium is to destroy the barrier function of stratum corneum, reducing the resistance of drug transport through the skin and increasing the diffusion coefficients of osthol.

Key words: osthol, osthol, percutaneous absorption, percutaneous absorption, gel, gel, penetration enhancers, penetration enhancers

CLC Number:

R943.43

R944.15

Supporting:

YUAN Zhen-ting, DING Ping-tian^*, Lu Bo, CHEN Da-wei. In Vitro Skin Permeation of Osthol from Hydro-Alcoholic Gel Formulations[J]. .

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