http://jcps.bjmu.edu.cn

• Full Papers • Previous Articles     Next Articles

Chemical Constituents from Starfish Asterias rollestoni

LI Guo-qiang, DENG Zhi-wei , LI Jun, FU Hong-zheng, LIN Wen-han*   

  1. 1.State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China;
    2.Qingdao University of Science and Technology, Qingdao 266042, China;
    3.Chemical Test Center, Beijing Normal University, Beijing 100073, China
  • Received:2004-01-12 Revised:2004-05-10 Online:2004-06-15 Published:2004-06-15
  • Contact: LIN Wen-han*

Abstract: Aim To investigate novel bioactive and structural metabolites from marine organisms. Methods Column chromatography in association with semi-preparative HPLC were used for the isolation of compounds. 1D and 2D NMR, IR, UV, and MS were employed for structure elucidation. Results From the butanol fraction of the 95 % EtOH extract of the starfish Asterias rollestoni, a new compound N7-2’-deoxypseudoxanthosine (1), along with sixteen known compounds, 2’-O-methyl-inosine (2), 2’-deoxyinosine (3), 2’-O-methylguanosine (4), inosine (5) ; thymine (6), uracil (7), thymidine (8), deoxyuridine (9), 2’-O-methyluridine (10), (-)-(1S, 3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (11), (-)-(1R, 3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (12), (-)-(3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (13), L-tryptophan (14), L-phenylalanine (15), 3-carboxy indole (16), and p-hydroxybenzoic acid (17), have been isolated. Conclusion Compound 1 is a new natural product, and compounds 8, 9 and 10 are isolated from natural sources for the first time, and the known compounds except 14 and 15 are first reported from starfish Asterias rollestoni .

Key words: starfish, starfish, Asterias rollestoni, Asterias rollestoni, N7-2'-deoxypseudoxanthosine, N7-2'-deoxypseudoxanthosine

CLC Number: 

Supporting: