Synthesis of PNA Monomer by Ugi Four-Component Condensation Reaction

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Synthesis of PNA Monomer by Ugi Four-Component Condensation Reaction

WANG Wen-hao, ZHANG Ting, XU Ping^*

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China

Received:2003-01-05 Revised:2003-05-10 Online:2003-06-15 Published:2003-06-15
Contact: XU Ping*

Abstract

Abstract: Aim To improve the physico-chemical and biological properties, original PNAs were derivatized and modified; Methods Ugi four-component condensation reaction (Ugi 4-CC) was used to synthesize PNAs, in which the Fmocprotecting strategy was adopted; Results The Fmoc-protected PNA monomer and the key component isocyanide were synthesized; Conclusion A simple and changeable method for synthesis of PNA monomer has been developed.

Key words: peptide nucleic acids PNAs, peptide nucleic acids PNAs, Ugi reaction, Ugi reaction, monomer, monomer, isocyanide, isocyanide

CLC Number:

R914.4

Supporting:

WANG Wen-hao, ZHANG Ting, XU Ping^*. Synthesis of PNA Monomer by Ugi Four-Component Condensation Reaction[J]. .

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