Abstract: Objective: To study the effects of sodium magnesiusm fructose diphosphate (FDPM) on brain damage of rats after ischemia-reperfusion. Methods: Rats were subjected to cerebral ischemia-reperfusion induced by inserting a nylon thread into internal carotid artery to block the origin of middle cerebral artery and removing the thread later. FDPM (400 mg·kg^-1), fructose-1,6-diphosphate (FDP, 400 mg·kg^-1)and magnesium sulfate (MgSO4, 30 mg·kg^-1) were administrated 10 min after the onset of ischemia. Neurological scale, brain infarct area, Malondialdehyde (MDA) content and histopathological changes of brain tissue were studied. Results: FDPM decreased neurological scale, diminished brain infarct area, reduced MDA content and relieved histopathological change of rat brain tissue subjected to ischemia-reperfusion. These effects were more powerful than that of FDP or MgSO4. Conclusions: It is suggested that FDPM markedly prevented rats against brain damage after cerebral ischemia-reperfusion, and its effect was better than that of FDP or MgSO4.

Key words: Sodium magnesium fructose diphosphate, Sodium magnesium fructose diphosphate, Cerebral ischemia, Cerebral ischemia, Fructose-1,6-diphosphate, Fructose-1,6-diphosphate, Magnesium sulfate, Magnesium sulfate