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The Effects of Unsaturated Factors on Ring C to Chemical Properties of Podophyllotoxin Analogues

He Yong, Ma Weiyong, Zhang Chunnian   

  1. Shanghai Institute of Pharmaceutical Industry, 1320 Beijing Xi Road, Shanghai 200040
  • Received:2000-12-12 Revised:2001-01-15 Online:2001-06-15 Published:2001-06-15

Abstract: Podophyllotoxone, 4β-hydroxy-2,3-en-apopicropodophyllin, and 4-deoxy-4β-azado-2,3-en-apopicropodophyllin can easily transform to 4-hydroxy-dehydropicropodophyllin, dehydroanhydropicropodophllyin and 4-amino-dehydropicropodophyllin respectively in different conditions. These properties remind us to be careful in handling related compounds in similar conditions.

Key words: Podophyllotoxin, Analogue of podophyllotoxin

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