Abstract: Selectins are a new class of carbohydrate-binding glycoproteins which have been identified on the surface of specific cell types,such as leukocytes,platelets and uascular endothelium.It is now known that the selectin-carbohydrate recognition not only play key roles at early stage of the inflammatory reaction ,but also are very important for the invasion and metastasis of tumors.These results suggested that selectin antagonists can be used as anti-adhesive therapeutics to pathological inflammatory conditions,such as reperfusion injury,storke,etc.and will be helpful to the inhibition of the matastasis of tumor cells.