Abstract: The effect of multiglycosides of Tripterygium wilfordii Hook f.(GTW) on autoimmune syndrome (AIS) was studied. Campylobacter fetus ssp jejuni (CF-1) 3.6×10⁹ CFU×mL^-1 was injected intradermally on d0 to induce AIS. GTW 75 and 150 mg×kg^-1×d^-1 were given ig to mice from d14 to d28. Four weeks later, hind paw swelling of mice, serum anti-dsDNA antibody, serum anti-SRBC antibody, spleen lymphocyte proliferation were tested and IL-1 and TNF-α produced from macrophages were evaluated. The results showed that GTW reduced inflammatory swelling, suppressed serum anti-dsDNA antibody, serum hemolysin and spleen lymphocyte proliferation, inhibited IL-1 and TNF-αactivity. All results indicated that GTW had a theraputic effect on AIS in mice.

Key words: Tripterygium wilfordii Hook f, Tripterygium wilfordii Hook f, Autoimmune syndrome, Autoimmune syndrome, Anti-dsDNA antibody, Anti-dsDNA antibody, Serum hemolysin, Serum hemolysin, Lymphocyte proliferation, Lymphocyte proliferation, TNF-α, TNF-α, IL-1, IL-1