Synthesisof4(R)-(6-Amino-9H-Purine-9-yl)-2(R)-(Hydroxymethyl) tetrahydrofuran-3(R)-ol

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Synthesisof4(R)-(6-Amino-9H-Purine-9-yl)-2(R)-(Hydroxymethyl) tetrahydrofuran-3(R)-ol

Zhao Guisen, Vasu Nair

1. Department of Medicinal Chemistry, Shandong Medical University, Jinan 250012;
2. Department of Chemistry, the University of Iowa, U.S.A.

Received:1999-12-26 Revised:2000-04-20 Online:2000-09-15 Published:2000-09-15

Abstract

Abstract: 1-Deoxyribose (5), prepared from D-ribose via methylation, silylation and reductive cleavage, was converted into cyclic sulfite(7). Reaction of 7 with NaN3 resulted in azide (8), which was converted to the isomeric deoxy adenosine, 4(R)-(6-amino-9H-purin-9-yl)-2(R)-(hydroxymethyl) tetrahy-drofuran-3(R)-ol (1) by a sequence of five high-yield reactions. Antiviral studies are in progress.

Key words: Nucleoside, Nucleoside, Isodeoxyadenosine, Isodeoxyadenosine, Antiviral agent, Antiviral agent, Synthesis, Synthesis

Supporting:

Zhao Guisen, Vasu Nair . Synthesisof4(R)-(6-Amino-9H-Purine-9-yl)-2(R)-(Hydroxymethyl) tetrahydrofuran-3(R)-ol[J]. .

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Synthesisof4(R)-(6-Amino-9H-Purine-9-yl)-2(R)-(Hydroxymethyl) tetrahydrofuran-3(R)-ol

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