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Synthesis and Antitumor Activity of Antineoplaston A10 Analogs

Song Lin, Xie Yuli, Xie Yuyuan*   

  1. Shanghai Institute of Materia Medical Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031
  • Received:1999-08-25 Revised:1999-12-21 Online:2000-06-15 Published:2000-06-15
  • Contact: Xie Yuyuan*

Abstract: Analogs of Antineoplaston A10 were synthesized. Eight new Schiff bases were confirmed by elemental analysis and 1H NMR. Crystal of compound 7a was examined by X-ray in order to study the similarity of these molecules with Antineoplaston A10. Antitumor assay shows that they can inhibit P388 and A-549 at 10-4 mol·L-1.

Key words: Antineoplaston A10, Antineoplaston A10, Schiff base, Antitumor activity, Schiff base, Antitumor activity

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