Abstract:

The permeability of ondansetron at different current densities applied across the full-thickness mouse skin in vitro is reported. The steady state flux of ondansetron was increased from 30.29 μg·cm^-2·h^-1 to 160.70 μg.cm^-2·h^-1 When the current density changed from 0.05 mA·cm^-2 to 0.3 mA·cm^-2. But there was no strict linear relationship. Discoloration of ondansetron solution was found when platinum electrode was used in the donor compartment, which would be overcome by using Ag as electrode. The PH values in both donor and receptor compartments were changed in the study when platinum electrode was applied. The problems mentioned above and the keys to them were discussed.

Key words: Ondansetron, Transdermal iontophoretic delivery