Bovine Serum Albumin (BSA) Microspheres Containing Methotrexate II. Therapeutical Effects on Lung-bearing Sarcoma-180 in Mice

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Bovine Serum Albumin (BSA) Microspheres Containing Methotrexate II. Therapeutical Effects on Lung-bearing Sarcoma-180 in Mice

Xiao-Ping Chen, Ting-Sen Shi

Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850

Received:1992-06-03 Revised:1994-02-25 Online:1994-12-15 Published:1994-12-15

Abstract

Abstract: The mouse lung concentration of methotrexate (MTX) following the intravenous administration of MTX solution and MTX bovine serum albumin (BSA) microspheres was investigated. The therapeutic effects of the two MTX preparations on lung-bearing sarcomal-80 in mice were also studied. It was found that the AUC of the MTX microspheres group was about 7 times as much as that of the MTX solution group, and the MTX microspheres had better effects on lung-bearing sarcoma-180 than the MTX solution did.

Key words: Methotrexate, Sarcoma-180, Therapeutic effects, Bovine serum, Albumin microspheres

Supporting:

Xiao-Ping Chen, Ting-Sen Shi. Bovine Serum Albumin (BSA) Microspheres Containing Methotrexate II. Therapeutical Effects on Lung-bearing Sarcoma-180 in Mice[J]. .

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Bovine Serum Albumin (BSA) Microspheres Containing Methotrexate II. Therapeutical Effects on Lung-bearing Sarcoma-180 in Mice

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