Abstract: The addition of a number of adjuvants to Poloxamer 108 can diversely affect its cloud point. Poloxamer-modified soybean lecithin admixture (PSLA) can elevate the cloud point of the system to 125 ºC. The stabilizing effect on the diazepam submicronized emulsion (DSE) using PSLA as anemulsifying agent has been observed through particle size and zeta potential measurement. It was foundthat DSE had mean droplet size of 67.1 nm. The stability index was 1.06 and zeta potential was -27.15 mV, which was greater than that of DSE with the Poloxamer 108 as emulsifying agent only.

Key words: Poloxamer, Submicronized emulsion, Cloud point, Diazepam